Background: Spiritual support in nursing management plays a vital role in palliative care by improving patients’ quality of life, reducing anxiety, and enhancing emotional resilience in those with progressive, incurable conditions requiring holistic care.

Objective: To assess the effectiveness of the Spiritual Management Approach in improving the quality of life of palliative patients in hospitals.

Method: A quasi-experimental pre-test–post-test study was conducted on 50 respondents from two hospitals in North Sumatra, Indonesia, using simple random sampling. Data were collected through the SCCS and SF-36 questionnaires and analyzed statistically.

Result: The Spiritual Management Approach significantly improved patients’ quality of life, with mean scores increasing from 1.24 to 1.44 and a significant correlation (r = 0.381; p = 0.006).

Conclusion: Spiritual management effectively enhances nurses’ competence and patients’ well-being in palliative care.

Recommendation: Integration of spiritual management into nursing practice and further studies with larger samples and longer durations are recommended.

Adventy Riang Bevy Gulo completed his Master’s degree in Nursing at the University of Sumatera Utara, Indonesia. He is currently pursuing a PhD in Nursing at MAHSA University, Malaysia. His academic and professional interests include nursing, patient safety, nursing informatics, community health, health promotion, and nursing risk management. He is actively involved in teaching, research, and community engagement activities, with a particular interest in the development and implementation of digital health innovations to improve nursing practice and patient outcomes. His current doctoral research focuses on the design and implementation of a nursing risk prevention application to enhance patient safety. Through his academic and research activities, he is committed to contributing to the advancement of nursing science, healthcare innovation, and evidence-based nursing practice.