Arife Sancaktar
Akdeniz University Faculty of Medicine, TurkeyPresentation Title:
The impact of placental histopathology and maternal risk factors on neonatal morbidity in late preterm infants
Abstract
Background: Maternal risk factors and placental histopathological alterations are major determinants of neonatal morbidity in late preterm infants. This study aimed to investigate how maternal conditions interact with placental pathology to influence neonatal outcomes.
Methods: A prospective cohort of 62 late preterm infants (34⁰⁄₇–36⁶⁄₇ weeks) and their mothers was studied. Maternal risk factors—including preeclampsia, gestational diabetes, thrombophilia, oligohydramnios, and infection—were documented. Placental histopathology was categorized as maternal malperfusion, chronic inflammation, placentomegaly, hematoma, and others. Neonatal morbidities (hyperbilirubinemia, sepsis, feeding intolerance, intracranial hemorrhage, etc.) were statistically analyzed.
Results: Placental abnormalities were identified in 64.5% of cases. Maternal uterine malperfusion was significantly associated with neonatal hyperbilirubinemia (p=0.043) and intracranial hemorrhage (p=0.035). Chronic placental inflammation correlated with polycythemia (p=0.046), feeding intolerance (p=0.015), and rehospitalization (p=0.035). Placentomegaly was linked to early-onset neonatal sepsis (p=0.005) and feeding difficulties (p=0.011). Maternal preeclampsia, thrombophilia, oligohydramnios, and infections amplified these outcomes by contributing to placental insufficiency and inflammation.
Conclusion: Maternal risk factors and placental histopathological lesions jointly shape neonatal morbidity in late preterm infants. Integrating placental evaluation into perinatal care enhances early prediction and management of neonatal complications, emphasizing the placenta’s pivotal diagnostic value in maternal-fetal medicine.
Keywords: Late preterm, placenta, maternal risk factors, histopathology, neonatal morbidity, preeclampsia
Biography
Arife Sancaktar I am a 37-year-old pediatric specialist currently living in Antalya, Turkey. She received my medical degree in Pediatrics from Başkent University Hospital in Ankara in 2018. I am currently pursuing a subspecialty in Pediatric Cardiology at Akdeniz University Hospital in Antalya.
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