Anastasiya Kubyshkina
Resuscitator of the Neonatal Intensive Care Unit, Russian FederationTitle: The effect of hormonal adaptation on the cardio-respiratory system of late premature infants in the early neonatal period.
Abstract
The aim of the
work is to study the effect of hormonal status on cardio-respiratory adaptation
of late premature newborns in the early neonatal period. The study included 105 newborns with a
gestation period of 34-36 weeks. A comprehensive assessment of the early
adaptation period was carried out, the level of TSH, T3, T4 total, T4 free,
cortisol was determined. Blood sampling was carried out after birth from the
umbilical cord vein and on the 4th day from the subcutaneous veins. The
concentration of hormones was determined by the method of solid-phase enzyme
immunoassay using standard sets of "Alkor Bio Company" (Russia).
Newborns in need of respiratory and cardiotonic therapy had reduced
concentrations of T3, T4 free and cord blood cortisol. On the 4th day of life,
newborns in need of respiratory therapy showed a decrease in free T4 and an
increase in cortisol, children receiving cardiotonic support had a reduced
concentration of free T4. Hormonal
maladaptation can be considered as an additional factor in the pathogenesis of
respiratory disorders in late premature newborns along with a reduced gas
exchange area in the lungs, immaturity of sodium pumps in alveolocytes and
surfactant deficiency
Biography
Anastasiya
Kubyshkina received a doctor's degree in 2017. Currently, he works as a
resuscitator in the Neonatal Intensive Care unit of the Perinatal center of
Voronezh, Russia. He is also a postgraduate student at the Voronezh State
Medical University named after N.N. Burdenko and is preparing a dissertation on
the topic "Early hormonal adaptation of late premature newborns".
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