Svetlana O Dubrovina

Rostov State Medical University, Russian Federation

Title: Treatment of Endometriosis – Focus on Improving Quality of Life

Abstract

Context: Endometriosis is a chronic gynecologic disease that affects up to 10% of women in reproductive age. It is associated with pelvic pain, dysmenorrhea and infertility and has a considerable negative effect on the health-related quality of life (QoL). The main goal of medical treatment is to minimize the need for surgery and decrease the risk of postoperative endometriosis recurrence. Also, it is very important to preserve and improve patients’ QoL. Progestogens are used as a first-line therapy of endometriosis, but there is a lack of data about this therapy influence on QoL.

Objective: To assess the effect of progestogen therapy in the management of endometriosis on patients’ QoL and to compare it between prolonged cyclical and continuous treatment regimens of dydrogesterone.

Methods: Observational, prospective cohort study over 6 months.

Patient(s): Three hundred fifty women aged from 18 to 45 years with verified endometriosis and chronic pelvic pain with or without dysmenorrhea.

Intervention(s). Dydrogesterone 10 mg 2 or 3 times daily, either between the 5th and 25th days of the menstrual cycle (prolonged cyclical treatment regimen) or continuously (continuous treatment regimen). For all patients, the data cutoff was at six months of treatment.

Main Outcome Measure(s). The change in QoL was assessed according to the Short Form-20 at the end of observation versus baseline. The analysis was conducted using the Wilcoxon Rank Sum Test.

Result(s). In the full population, assessment of QoL according to the SF-20 showed statistically significant improvement (p<0.0001) of all assessed parameters at the middle and to the end of the treatment compared to baseline. To the end of the treatment the mean improvements in QoL parameters were as follows: Perceived health status +19.9 ± 18.3 (median 20.0); Mental health +18.8 ± 16.3 (median 20.0); Pain -28.4 ± 24.0 (median -20.0); Physical functioning +20.1 ± 23.7 (median 17.0); Role functioning +38.5 ± 46.9 (median 0); Social functioning +20.0 ± 23.6 (median 20.0). Changes in the QoL parameters were not significantly different between two (prolonged cyclical and continuous) treatment regimes.

Conclusions. Endometriosis can be effectively treated with preservation of QoL using dydrogesterone. According to the results dydrogesterone therapy shows the same effectiveness in patients' QoL improvement in both prolonged cyclical and continuous treatment regimens.

Biography

Dr. Svetlana O Dubrovina, Department of Obstetrics and Gynecology, Federal State Budgetary Educational Institution of Higher Education, Rostov State Medical University, Ministry of Healthcare of the Russian Federation, Rostov-on-Don, Russian Federation

3rd International Conference on Midwifery and Neonatal Care

Svetlana O Dubrovina

Title: Treatment of Endometriosis – Focus on Improving Quality of Life

Abstract

Biography

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