Zewudu Mulatie
Sciences of Wollo , EthiopiaTitle: Hematological Profiles of Newborns of Mothers with Hypertensive Disorders of Pregnancy Delivered at the University of Gondar Comprehensive Specialized Hospital: A Comparative Cross-Sectional Study
Abstract
Hypertensive
disorders in pregnancy can cause prenatal placental perfusion with insufficient
blood supply to the fetus, resulting in fetal exposure to hypoxia and leading
to disturbance of neonatal hematopoietic stem cells. This study aimed to
compare the hematological profiles of newborns from mothers with hypertensive
disorders and normotensive delivered at the University of Gondar comprehensive
specialized hospital.
Methods: A
comparative cross-sectional study was conducted from March to May 2022 among
308 newborns from hypertensive and normotensive mothers in equal proportions. A
systematic random sampling technique was used to select study participants.
Independent t-test and Mann-Whitney U test were done to compare the
hematological profiles of the two groups. P-value <0.05 were considered
statistically significant.
Results: The
hematocrit levels were significantly higher in neonates of hypertensive mothers
than the neonates of normotensive mothers (49.10 ± 5.19% and 46.09 ± 7.63%
respectively) (P<0.001) while neutrophil counts were significantly lower in
neonates of hypertensive mothers than the neonates of normotensive mothers
(6.62 ± 3.30 and 7.55 ± 3.31 x103 /ul respectively) (P=0.007). Also, platelets
counts were significantly lower in neonates of hypertensive mothers than
neonates of normotensive mothers (221.25 ± 83.56 and 260.24 ± 83.01 x103/ul
respectively) (P<0.001). The platelet and nucleated red blood cell count
showed a statistically significant difference among newborns from mothers with
superimposed preeclampsia and gestational hypertension.
Conclusion: Newborns
delivered from hypertensive disorders of pregnancy had low white blood cell
parameters, low platelet count and high red blood cell parameters compared to
controls. As result, newborns may develop leukopenia, thrombocytopenia and
polycythemia, respectively. Therefore, newborns should be monitored for early
detection and follow-up of hematological abnormalities before complications
occurred.
Keywords:
Hematological profile, hypertensive disorder, newborns, Gondar, Ethiopia
Biography
Zewudu Mulatie is Masters in Hematology & Immunohematology unit from
Department of Medical Laboratory Sciences of Wollo University
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